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Bentley compounds : ウィキペディア英語版
Bentley compounds
The Bentley compounds are a class of semi-synthetic opioids that were first synthesized by K. W. Bentley by Diels-Alder reaction of thebaine with various dienophiles. The compounds are properly known as thevinols and orvinols, or "bridged oripavine derivatives", due to the characteristic 6,14-''endo''-etheno- bridge and substitution at the 7α position. Buprenorphine and etorphine are perhaps the best known of the family, which was the first series of extremely potent μ-opioid agonists, with some compounds in the series having over many thousands of times the analgesic potency of morphine.
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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